Endocrine Abstracts

Background: In the multifarious etiopathogenesis of skeletal fragility, an intriguing novel element is the possible existence of a crosstalk between autonomic nervous system (ANS) function and bone health. Indeed, sympathetic overactivity might stimulate osteoclastogenesis and inhibit osteoblastic proliferation, whereas opposite effects would be exerted by a prevalent parasympathetic activation. Autonomic Nervous System Index (ANSI) is a percent ranked (0–100) unitary pro...

Background: Late-onset central hypogonadism (LOH), whose prevalence is high among dysmetabolic males, impairs quality of life and increases cardiovascular risk. Although lifestyle modification is the first-line therapeutic strategy, it often fails in clinical practice, probably due to socio-cultural, economic and organisational barriers, as well as the lack of effective and sustainable intervention programs.Aim: To delineate sustainable physical exercise...

Background: Recent data suggest a direct effect of follicle stimulating hormone (FSH) on the skeletal metabolism. Particularly, it can encourage bone resorption and also inhibit osteoblast differentiation. High FSH levels have been found to correlate with impaired bone health in females, whilst evidence in males remains somewhat poor and conflicting. Intriguingly, men with primary and central hypogonadism might represent a novel study model in this context.<p class="abstex...

Background: Metabolic syndrome (MetS) represents a huge public health problem worldwide, being associated with an increased risk of cardiovascular and oncological diseases, and all-cause mortality. There is compelling evidence supporting a key role of dysfunctional autonomic nervous system (ANS) in such an association as well as the mutual correlation between the components of MetS. Autonomic Nervous System Index (ANSI) is a percent ranked (0–100) unitary proxy of cardiac...

Exercise is one of the major determinants of a healthy lifestyle, being crucial in childhood as a powerful preventive tool. On the other hand, obesity and arterial hypertension rate has been increasing in children, thus increasing the risk of developing cardiovascular and metabolic diseases in adult life. Of vital importance is the modality and volume of exercise required to get benefits. In this feasibility study 35 obese children were enrolled. Autonomic and metabolic contro...